研究業績

藤本研究室で発表された論文・特許・総説を紹介しています。

Papers List

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002

2024

[3] UltraFast PhotoInduced double duplex DNA invasion into a 400-mer dsDNA target
Siddhant Sethi; Zumila Halili; Yasuha Watanabe; Junling Mo; Kenzo Fujimoto*
Bioorg. Med. Chem. Lett.,, 2024, in press,
DOI: 10.1016/j.bmcl.2023.129597

[2]
藤本健造
特願2024-013725, 2024,

[1]
藤本健造
特願2024-011378, 2024,

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2023

[2] Acceleration of the Deamination of Cytosine through Photo-Crosslinking
Siddhant Sethi; Yasuharu Takashima; Shigetaka Nakamura; Licheng Wan; Nozomi Honda; Kenzo Fujimoto*
Curr. Issues Mol. Biol, 2023, 45, 6, 4687 - 4700
DOI: 10.3390/cimb45060298

[1] Effect of hydrophilic changes in base pair mismatches on deamination of cytosine photo-crosslinked to 3-cyanovinylcarbazole.
Siddhant Sethi; Kanako Ishino; Kai Takeda; Shiegetaka Nakamura; Kenzo Fujimoto*
Chemistry Letters, 2023, 52, 4, 273 - 275
DOI: 10.1246/cl.230055

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2022

[3] Monotone Control of R Systems
Ryutaro Yako; Daihei Ise; Ken Komiya; Kenzo Fujimoto; Satoshi Kobayashi*
New Generation Computing, 2022, 40, 623 - 657
DOI: 10.1007/s00354-022-00166-2

[2] Photoinduced Aggregation of Liposome modified with DNA containing Ultrafast DNA Photo-cross-linker
Kenzo Fujimoto*; Masakatsu Ichikawa; Shigetaka Nakamura
Journal of Chemical Technology & Biotechnology, 2022, 97, 1, 295 - 298
DOI: 10.1002/jctb.6941

[1] Molecular Robotics (Books)

ISBN: 978-981-19-3987-7 Springer Nature Singapore, 2022, Chapter 7,
DOI: 10.1007/978-981-19-3987-7

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2021

[5] The inhibition effect of photo-cross-linking between probes in photo-induced double duplex invasion DNA
Kenzo Fujimoto*; Ayumu Hirano; Yasuha Watanabe; Ami Shimabara; Shigetaka Nakamura
ChemBioChem, 2021, 22, 24, 3402 - 3405
DOI: 10.1002/cbic.202100430

[3] Photo-cross-linking of DNA using 4-methylpyranocarbazole nucleoside with thymine-base selectivity
Jun-ichi Mihara; Kenzo Fujimoto*
Organic & Biomolecular Chemistry, 2021, 45, 9860 - 9866
DOI: 10.1039/D1OB01621K

[2] The effect of 5-substituent in cytosine to the photochemical C to U transition in DNA strand
Kenzo Fujimoto*; Wan Licheng; Shigetaka Nakamura
Bioorg. Med. Chem. Lett., 2021, 35, 127812
DOI: 10.1016/j.bmcl.2021.127812

[1] Reducing the size of Control Alphabet for the Control of Right Linear Grammar with Unknown Behaviors
Nobuya Kimoto; Shigetaka Nakamura; Ken Komiya; Kenzo Fujimoto; Satoshi Kobayashi*
Theoretical Computer Science, 2021, 862, 193 - 213
DOI: 10.1016/j.tcs.2020.11.051

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2020

[7] Fluorescence In Situ Hybridization of 16S rRNA in Escherichia coli Using Multiple Photo-Cross-Linkable Probes
Kenzo Fujimoto*; Nanami Watanabe
ChemistrySelect, 2020, 5, 46, 14670 - 14676
DOI: 10.1002/slct.202003343

[6] Complete Photochemical Regulation of 8-17 DNAzyme Activity using Reversible DNA Photo-cross-linking
Yasuha Watanabe; Kenzo Fujimoto*
ChemBioChem, 2020, 21, 22, 3244 - 3248
DOI: 10.1002/cbic.202000227

[5] Photochemical RNA editing of C to U using ultrafast reversible RNA photo-cross-linking in DNA/RNA duplexes
Shigetaka Nakamura; Kanako Ishino; Kenzo Fujimoto*
ChemBioChem, 2020, 21, 21, 3067 - 3070
DOI: 10.1002/cbic.202000269

[4] Effect of linker length on photo-cross-linking position mediated by click chemistry via [2+2]photocycloaddition
Kenzo Fujimoto*; Kenta Ishida; Li Xue; Shigetaka Nakamura
Photochemical & Photobiological Sciences, 2020, 19, 776 - 782
DOI: 10.1039/D0PP00098A

[3] Simultaneous Amino Acid Analysis Based on F-19 NMR Using a Modified OPA-Derivatization Method
Takashi Sakamoto*; Zhiyong Qiu; Miyu Inagaki; Kenzo Fujimoto*
Analytical Chemistry, 2020, 92, 2, 1669 - 1673
DOI: 10.1021/acs.analchem.9b0

[2] 核酸科学ハンドブック　（日本核酸化学会監修）
藤本健造
ISBN: 978-4-06-520786-4 講談社, 2020, 第II部　核酸科学の最前線, 443

[1]
藤本健造
特願2020-144604, 2020,

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2019

[9] DNA photo-cross-linking using pyranocarbazole modified oligodeoxynucleotide with D-threoninol linker
Kenzo Fujimoto*; Tsubasa Yamaguchi; Takahiro Inatsugi; Masahiko Takamura; Isao Ishimaru; Ayako Koto; Shigetaka Nakamura
RSC Advances, 2019, 9, 30693 - 30697
DOI: 10.1039/C9RA06145B

[8] RNA Fluorescence In Situ Hybridization using Photo-cross-linkable Beacon Probes Containing Pyranocarbazole in Living E. coli
Kenzo Fujimoto*; Misaki Hashimoto; Nanami Watanabe; Shigetaka Nakamura
Bioorg. Med. Chem. Lett.,, 2019, 29, 16, 2173 - 2177
DOI: 10.1016/j.bmcl.2019.06.051

[7] Reversible photo-cross-linking of GCN4 peptide containing 3-cyanovinylcarbazole amino acid to double-stranded DNA
Zhiyong Qiu; Shigetaka Nakamura; Kenzo Fujimoto*
Organic &Biomolecular Chemistry, 2019, 17, 6277 - 6283
DOI: 10.1039/C9OB00372J

[6] Strong inhibitory effects of antisense probes on gene expression through ultrafast RNA photo-crosslinking
Kenzo Fujimoto*; Hung Yang; Shigetaka Nakamura
Chemistry - An Asian Journal, 2019, 14, 11, 1912 - 1916
DOI: 10.1002/asia.201801917

[5] Monotonically Controlling Regular Grammars with Unknown Behaviors to Output a Target String
Nobuya Kimoto; Ken Komiya; Kenzo Fujimoto; Satoshi Kobayashi*
Theoretical Computer Science , 2019, 777, 387 - 408
DOI: 10.1016/j.tcs.2019.01.009

[4] CNVK and CNVD - ultrafast reversible photo-cross-linkers for DNA or RNA
Kenzo Fujimoto*
Glen Report (news letter vol 30(2)) , 2019, 1 - 4

ダウンロード先

[3] 光化学的DNA及びRNA操作法の開発ーゲノムDNAの光操作・RNA光編集に向けてー
藤本健造
Medical Science Digest「ゲノム編集の最近の進歩」　ニューサイエンス社　, 2019, 45, 9, 48 - 49

[2]
藤本健造; 三原純一
特願2019-19115, 2019,

[1]
藤本健造; 三原純一
特願2019-14890, 2019,

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2018

[9] Ultra‐acceleration of Photochemical Cytosine Deamination by 5'‐phosphate ODN probe containing 3‐Cyanovinylcarbazole at 5'‐end
Siddhant Sethi; Nozomi Honda; Licheng Wan; Shigetaka Nakamura; Kenzo Fujimoto*
ChemBioChem, 2018, 19, 21, 2257 - 2261
DOI: 10.1002/cbic.201800384

[8] DNA Photo-cross-linking Using Pyranocarbazole and Visible Light
Kenzo Fujimoto*; Shinobu Sasago; Junichi Mihara; Shigetaka Nakamura
Org. Lett., 2018, 20, 10, 2802 - 2805
DOI: 10.1021/acs.orglett.8b00593

[7] DNA photocrosslinking using 3-vinylcarbazole derivatives in two-color detection of methylcytosine
Shigetaka Nakamura; Ryou Nakajima; Kenzo Fujimoto*
Chem. Lett., 2018, 47, 7, 875 - 877
DOI: 10.1246/cl.180205

[6] Multiplexed detection of nucleic acids using 19F NMR chemical shift change based on DNA photo-cross-linking of 3-vinylcarbazole derivatives
Shigetaka Nakamura; Yasuharu Takashima; Kenzo Fujimoto*
Organic & Biomolecular Chemistry, 2018, 16, 891 - 894
DOI: 10.1039/C7OB03008H

[5] Study of Photochemical Cytosine to Uracil Transition via Ultrafast Photo-Cross-Linking Using Vinylcarbazole Derivatives in Duplex DNA
Siddhant Sethi; Shigetaka Nakamura; Kenzo Fujimoto*
Molecules, 2018, 23, 4, 828 - 937
DOI: 10.3390/molecules23040828

[4] Disassembly-driven Signal Turn-on Probes for Bimodal Detection of DNA with 19F NMR and Fluorescence
Takashi Sakamoto*; Takashi Hasegawa; Kenzo Fujimoto*
Organic &Biomolecular Chemistry, 2018, 16, 7157 - 7162
DOI: 10.1039/C8OB02218F

[3] "Photo-Cross-Linkable Artifitial Nucleic Acid:Synthesis and Properties..." in "Synthesis of Therapeutic Oligonuleotide"
Takashi Sakamoto; Kenzo Fujimoto
Springer, 2018, Chapter 10, 171 - 186
DOI: 10.1007/978-981-13-1912-9_10

[2] 光架橋性人工核酸の合成と応用（第５章）
藤本健造; 中村重孝
「中分子創薬に資するペプチド・核酸・糖鎖の合成技術」　シーエムシー出版, 2018,

[1]
藤本健造; 中村重孝
特願2018-72685, 2018,

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2017

[12] A multiplex RNA quantification method to determine the absolute amounts of mRNA without reverse transcription
Maasa Yokomori; Osamu Gotoh; Yasufumi Murakami; Kenzo Fujimoto; Akira Suyama
Analytical Biochemistry, 2017, 539, 96 - 103
DOI: 10.1016/j.ab.2017.10.006

[11] Photo-triggered sequence-specific DNA transportation into liposomes using ultrafast DNA photo-cross-linking
Shigetaka Nakamura; Nobuharu Uehara; Takashi Hasegawa; Kenzo Fujimoto*
Chem. Lett., 2017, 46, 1839 - 1840
DOI: 10.1246/cl.170835

[10] Wash-free RNA FISH using a photoresponsive beacon probe via photochemical cross-linking
Shigetaka Nakamura; Chinami Kano; Kenzo Fujimoto*
Chem. Lett, 2017, 46, 1711 - 1712
DOI: 10.1246/cl.170738

[9] Photochemical acceleration of DNA strand displacement using ultrafast DNA photo-cross-linking
Shigetaka Nakamura; Hirokazu Hashimoto; Satoshi Kobayashi; Kenzo Fujimoto*
ChemBioChem, 2017, 18, 20, 1984 - 1989
DOI: 10.1002/cbic.201700430

[8] Double duplex invasion of DNA induced by ultrafast photo-cross-linking using 3-cyanovinylcarbazole toward for antigene method
Shigetaka Nakamura; Hayato Kawabata; Kenzo Fujimoto*
Chemical Communications, 2017, 53, 7616 - 7619
DOI: 10.1039/C7CC01746D

[7] Effect of substitution of photo-cross-linker in photochemical cytosine to uracil transition in DNA
Siddhant Sethi; Yasuharu Takashima; Shigetaka Nakamura; Kenzo Fujimoto*
Bioorg. Med. Chem. Lett.,, 2017, 27, 16, 3905 - 3908
DOI: 10.1016/j.bmcl.2017.06.042

[6] Development of 19F-NMR chemical shift detection of DNA B-Z equilibrium using 19F-NMR
Shigetaka Nakamura; Yang Hui; Chihiro Hirata; Florian Kersaudy; Kenzo Fujimoto*
Organic & Biomolecular Chemistry , 2017, 15, 5109 - 5111
DOI: 10.1039/C7OB00706J

[5] Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside
Siddhant Sethi; Minako Ooe; Takashi Sakamoto; Kenzo Fujimoto*
Molecular BioSystems, 2017, 13, 1152 - 1156
DOI: 10.1039/C7MB00082K

[4] Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy
Hong-Liang Bao; Takumi Ishizuka; Takashi Sakamoto; Kenzo Fujimoto; Tamayo Uechi; Naoya Kenmochi; Yan Xu*
Nucleic Acids Research, 2017, 45, 9, 5501 - 5511
DOI: 10.1093/nar/gkx109

[3] 細胞内核酸類の操作に向けた化学的アプローチ
中村重孝; 藤本健造
月刊「化学」：最新のトピックス, 2017, 72, 4, 64 - 65

[2]
藤本健造; 中村重孝
特願2017-144955, 2017,

[1]
藤本健造; 中村重孝
特願2017-144897, 2017,

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2016

[8] RNA fluorescence in situ hybridization using 3-cyanovinylcarbazole modified oligodeoxyribonucleotides as photo-cross-linkable probes
Kenzo Fujimoto*; Kei Toyosato; Shigetaka Nakamura; Takashi Sakamoto
Bioorg. Med. Chem. Lett.,, 2016, 26, 5312 - 5314
DOI: 10.1016/j.bmcl.2016.09.035

[7] Sequence-specific DNA photo-splitting of 3-cyanovinylcarbazole using DNA strand displacement
Shigetaka Nakamura; Hayato Kawabata; Kenzo Fujimoto*
ChemBioChem, 2016, 17, 16, 1499 - 1503
DOI: 10.1002/cbic.201600236

[6] Effect of 5-substitution of uracil base in DNA photo-cross-linking using 3-cyanovinylcarbazole
Shigetaka Nakamura; Hayato Kawabata; Hodaka Muramatsu; Kenzo Fujimoto*
Chem. Lett., 2016, 45, 8, 887 - 889
DOI: 10.1246/cl.160382

[5] Reversible Gel-Sol Transition of Photo-Responsive DNA Gel
Daisuke Kandatsu; Ibuki Kawamata; Shogo Hamada; Shin-ichiro M. Nomura; Kenzo Fujimoto; Satoshi Murata*
ChemBioChem, 2016, 17, 12, 1118 - 1121
DOI: 10.1002/cbic.201600088

[4] UVA Responsive Anticancer Prodrugs Based on Photoinduced Electron Injection into Oligonucleotide Having 5-Halouracils
Kenzo Fujimoto*; Mirei Furusawa; Shigetaka Nakamura; Takashi Sakamoto
Chem. Lett., 2016, 45, 9, 1078 - 1080
DOI: 10.1246/cl.160492

[3] Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using fluorine-modified bisbenzimide derivative
Takashi Sakamoto*; Daisaku Hasegawa; Kenzo Fujimoto*
Analyst, 2016, 141, 1214 - 1217
DOI: 10.1039/C5AN02389K

[2] "Photo-Cross-Linking reaction in Nucleic Acids: Chemistry and Applications" in “Mofified Nucleic Acids”
Takashi Sakamoto; Kenzo Fujimoto
Springer, 2016, Chapter 7, 145 - 158

ISBN: 978-3319271095

[1]
藤本健造; 中村重孝
特願2016-105622, 2016,

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2015

[7] A versatile puromycin-linker using cnvK for high-throughput in vitro selection by cDNA display
Yuki Mochizu; Takeru Suzuki; Kenzo Fujimoto; Naoto Nemoto*
Journal of Biotechnology, 2015, 212, 174 - 180
DOI: 10.1016/j.jbiotec.2015.08.020.

[6] Critical Effect of Base Pairing of Target Pyrimidine on the Inter-strand Photo-cross-linking of DNA via 3-Cyanovinylcarbazole Nucleoside
Takashi Sakamoto; Minako Ooe; Kenzo Fujimoto*
Bioconjugate Chemistry, 2015, 26, 8, 1475 - 1478
DOI: 10.1021/acs.bioconjchem.5b00352

[5] Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced large shifted 19F MR signal
Shigetaka Nakamura; Kenzo Fujimoto*
Chemical Communications, 2015, 51, 11765 - 11768
DOI: 10.1039/C5CC02972D

[4] Fluorine-modified bisbenzimide derivative as a molecular probe for bimodal and simultaneous detection of DNAs by 19F NMR and fluorescence
Takashi Sakamoto*; Daisaku Hasegawa; Kenzo Fujimoto*
Chemical Communications, 2015, 51, 8749 - 8752
DOI: 10.1039/C5CC01995H

[3] DNA Photo-cross-linking using 3-Cyanovinylcarbazole Modified Oligonucleotide with Threoninol Linker
Takashi Sakamoto; Yuya Tanaka; Kenzo Fujimoto*
Organic Letters, 2015, 17, 4, 936 - 939
DOI: 10.1021/acs.orglett.5b00035

[2] 光化学的な超高速核酸類操作法とその応用
藤本健造; 中村重孝
光アライアンス, 2015, 3, 37

[1]
坂本隆; 藤本健造
特願2015-44611, 2015,

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2014

[7] Photo-regulation of constitutive gene expression in living cells by using ultrafast photo-cross-linking oligonucleotides
Takashi Sakamoto; Atsuo Shigeno; Yuichi Ohtaki; Kenzo Fujimoto*
Biomaterials Science, 2014, 2, 9, 1154 - 1157
DOI: 10.1039/C4BM00117F

[6] Rapid potopolymerization of oligonucleotides by 3-cyanovinylcarbazole mediated DNA photocrosslinking
Shigetaka Nakamura; Kenzo Fujimoto*
Journal of Photopolymer Sciecne and Technology, 2014, 27, 4, 485 - 490
DOI: 10.2494/photopolymer.27.485

[5] Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner
Kenzo Fujimoto*; Yu-ki Takematsu; Atsuo Shigeno; Mirei Furusawa; Takashi Sakamoto
Bioorg. Med. Chem. Lett., 2014, 24, 16, 3736 - 3738
DOI: 10.1016/j.bmcl.2014.07.002.

[4] Creation of DNA Array Structure Equipped with heat resistance by Ultrafast Photocrosslinking
Shigetaka Nakamura; Kenzo Fujimoto*
Journal of Chemical Technology & Biotechnology , 2014, 89, 1086 - 1090
DOI: 10.1002/jctb.4205

[3]
藤本健造; 中村重孝
特願2014-224574, 2014,

[2]
藤本健造; 坂本隆; 大江美成子
特願2014-073943, 2014,

[1]
藤本健造; 中村重孝
特願2013-259334, 2014,

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2013

[9] Details of the ultra-fast DNA photocrosslinking reaction of 3-cyanovinylcarbazole nucleoside; Cis-trans isomeric effect and the application for SNP based genotyping
Kenzo Fujimoto*; Asuka Yamada; Yoshinaga Yoshimura; Tadashi Tsukaguchi; Takashi Sakamoto
J. Am. Chem. Soc., 2013, 135, 43, 16161 - 16167
DOI: 10.1021/ja406965f

[8] Geometric Effect on the Photocrosslinking Reaction between 3-Cyanovinylcarbazole Nucleoside and Pyrimidine Base in DNA/RNA Heteroduplex
Kenzo Fujimoto*; Satomi Kishi; Takashi Sakamoto
Photochemistry and Photobiology, 2013, 89, 5, 1095 - 1099
DOI: 10.1111/php.12118.

[7] Creation of DNA Array Structure Equipped with heat resistance by Ultrafast Photocrosslinking
Shigetaka Nakamura; Kenzo Fujimoto
Journal of Chemical Technology & Biotechnology, 2013,
DOI: 10.1002/jctb.4205

[6] Quick and Reversible Photocrosslinking Reaction of 3-Cyanovinylcarbazole Nucleoside in DNA Triplex
Kenzo Fujimoto*; Hiroki Yoshinaga; Yasumasa Yoshio; Takashi Sakamoto
Organic & Biomolecular Chemistry, 2013, 11, 5065 - 5068
DOI: 10.1039/C3OB40915E

[5] Quick, Selective and Reversible Photocrosslinking Reaction between 5-Methylcytosine and 3-Cyanovinylcarbazole in DNA Double Strand
Kenzo Fujimoto*; Kaoru Konishi-Hiratsuka; Takashi Sakamoto
Int. J. Mol. Sci, 2013, 14, 5765 - 5774
DOI: 10.3390/ijms14035765

[5] Diamine Derivatives Accelerate Photochemical C→U Transition in DNA Double Strand
Kenzo Fujimoto*; Daiki Futamura; Takashi Sakamoto
Chem. Lett, 2013, 42, 289 - 291
DOI: 10.1246/cl.2013.289

[3]
藤本健造; 中村重孝
特願2013-225799, 2013,

[2]
藤本健造; 坂本隆; 田中佑弥
特願2013-70381, 2013,

[1]
藤本健造; 中村重孝; 橋本浩寿; 小林聡
特願2013-133163, 2013,

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2012

[5] Quick Regulation of mRNA Functions by a Few Seconds of Photoirradiation
Atsuo Shigeno; Takashi Sakamoto; Yoshinaga Yoshimura; Kenzo Fujimoto
Organic & Biomolecular Chemistry, 2012,
DOI: 10.1039/C2OB25883H

[4] 5-Methylcytosine Selective Photoligation Using Photoresponsive Oligonucleotides Containing Various 5-Vinyl-2¤-deoxyuridines Having an Aromatic Group
Takashi Sakamoto; Takehiro Ami; Kenzo Fujimoto
Chem. Lett., 2012, 41(1), 47-49,
DOI: 10.1246/cl.2012.47

[3] Specific and reversible photochemical labeling of plasmid DNA using photoresponsive oligonucleotides containing 3-cyanovinylcarbazole
Kenzo Fujimoto; Kaoru Hiratsuka-Konishi; Takashi Sakamoto; Tomoko Ohtake; Ken-ichi Shinohara; Yoshinaga Yoshimura
Molecular BioSystems, 2012, 8(2), 491-494,
DOI: 10.1039/C2MB05422A

[2] Template Directed Reversible Photochemical Ligation of Oligodeoxynucleotides
Shigetaka Nakamura; Shinzi Ogasawara; Shigeo Matuda; Isao Saito; Kenzo Fujimoto
Molecules, 2012, 17, 163-178,
DOI: 10.3390/molecules17010163

[1]
藤本健造; 中村重孝
特願2012-159889, 2012,

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2011

[6] Stabilization of DNA nanostructures by photo-cross-linking
Miho Tagawa; Koh-ichiroh Shohda; Kenzo Fujimoto; Akira Suyama
Soft Matter, 2011, 7, 10931-10934,
DOI: 10.1039/C1SM06303K

[5] Signal turn-on probe for nucleic acid detection based on 19F nuclear magnetic resonance
Takashi Sakamoto; Yu-ki Shimizu; Jun Sasaki; Hikaru Hayakawa; Kenzo Fujimoto
Bioorg.Med.Chem.Lett, 2011, 21(1), 303-306,
DOI: 10.1016/j.bmcl.2010.11.013.

[4] Construction of branched DNA for SNP determination on glass-chip using photochemical ligation
Minhaz Uddin Ahmed; Yoshinaga Yoshimura; M. Mosharraf Hossain; Eiichi Tamiya; Kenzo Fujimoto
BioChip J., 2011, 5(3), 206-221,
DOI: 10.1007/s13206-011-5303-0

[3] Development of a Potassium Ion Sensor for 19F Magnetic Resonance Chemical Shift Imaging Based on Fluorine-labeled Thrombin Aptamer
Takashi Sakamoto; Hikaru Hayakawa; Kenzo Fujimoto
Chem. Lett., 2011, 40, 720,
DOI: 10.1246/cl.2011.720

[2] Possibility of genetic restoration for a disease treatment
Toshifumi Tsukahara; Yu Ooka; Shafiul Alam; Hitoshi Suzuki; Kenzo Fujimoto
IEEE ICMSAO, 2011,
DOI: 10.1109/ICMSAO.2011.5775517

[1] 光で操るDNA
藤本健造
パリティ　特集「DNAの物理」, 2011, 26(9),

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2010

[6] Site-Specific Photochemical RNA Editing
Kenzo Fujimoto; Kaoru Konishi-Hiratsuka; Takashi Sakamoto; Yoshinaga Yoshimura
Chemical Communications, 2010, 46, 7545,
DOI: 10.1039/C0CC03151H

[5] The Site-Specific Cytosine to the Uracil Transition Using Reversible DNA Photocrosslinking
Kenzo Fujimoto; Takashi Sakamoto; Kaoru Konishi-Hiratsuka; Yoshinaga Yoshimura
ChemBioChem, 2010, 11, 1661,
DOI: 10.1002/cbic.201000274

[4] Photoreversible DNA end capping for the formation of hairpin structures
Yoshinaga Yoshimura; Hajime Okada; Kenzo Fujimoto
Organic & Biomolecular Chemistry, 2010, 8, 1523,
DOI: 10.1039/b924989c

[3] Surface-enhanced Raman spectroscopy for facile DNA detection using gold nanoparticle aggregates formed via photoligation
Nguyen T. B. Thuy; Ryoko Yokogawa; Yoshinaga Yoshimura; Kenzo Fujimoto; Mikio Koyano; Shinya Maenosono
Analyst, 2010, 135(3), 595,
DOI: 10.1039/b919969a

[2] Development of Photochemical DNA/RNA Manipulation Toward Its Application for Nanotechnology
Kenzo Fujimoto; Hideaki Yoshino; Tomoko Ohtake; Yoshinaga Yoshimura; Isao Saito
Trans. Mat. Res. Soc. J, 2010, 35, 85-89,
DOI: 10.14723/tmrsj.35.85

[1] 酵素を使わずに光で遺伝子を操作する
藤本健造
日本化学会、化学と教育, 2010, 2月,

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2009

[10] A new approach for reversible RNA photocrosslinking reaction: application to sequence-specific RNA selection
Yoshinaga Yoshimura; Tomoko Ohtake; Hajime Okada; Kenzo Fujimoto
ChemBioChem, 2009, 10, 1473,
DOI: 10.1002/cbic.200900057

[9] Detection of methylcytosine by DNA photoligation via hydrophobic interaction of the alkyl group
Masayuki Ogino; Yuuta Taya; Kenzo Fujimoto
Organic & Biomolecular Chemistry, 2009, 7, 3163,
DOI: 10.1039/b904941j

[8] SNP genotyping by using DNA photoligation: Application to SNP detection of genes from food crops
Yoshinaga Yoshimura; Tomoko Ohtake; Hajime Okada; Takehiro Ami; Tadashi Tsukaguchi; Kenzo Fujimoto
Science Technology of Advanced Materials, 2009, 10, 034603,
DOI: 10.1088/1468-6996/10/3/034603

[7] Photochemical ligation of DNA probe prepared in click chemistry
Takehiro Ami; Yoshimura Yoshinaga; Tomoya Matsuzaki; Kenzo Fujimoto
Journal of Photopolymer Sciecne and Technology, 2009, 22(2), 67,
DOI: 10.2494/photopolymer.22.267

[6] Development of a rapid and reversible photocrosslinking of RNA
Yoshinaga Yoshimura; Tomoko Ohtake; Hajime Okada; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2009, 53, 197,
DOI: 10.1093/nass/nrp099

[5] A photochemical detection of methylcytosine by using hydrophobic interaction
Takehiro Ami; Masayuki Ogino; Yuuta Taya; Yumiko Takemura; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2009, 53, 203,
DOI: 10.1093/nass/nrp102

[4] A selective and sensitive detection of SNP between rice cultivars by using DNA photoligation
Yoshinaga Yoshimura; Hajime Okada; Tomoko Ohtake; Tadashi Tsukaguchi; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2009, 53, 199,
DOI: 10.1093/nass/nrp100

[3] Highly selective detection of 5-methylcytosine using photochemical ligation
Masayuki Ogino; Yuuta Taya; Kenzo Fujimoto
Chemical Biology (Virtual Journal), 2009, 1,

[2] 光化学的に遺伝子を操作する
藤本健造
現代化学, 2009, 460,

[1] 酵素ではなく光を使ってDNAを操作する
藤本健造
銀行倶楽部　談話室, 2009, 510, 2,

↑ページトップへ

2008

[16] Highly selective detection of 5-methylcytosine using photochemical ligation
Masayuki Ogino; Yuuta Taya; Kenzo Fujimoto
Chemical Communications, 2008, 45, 5996,
DOI: 10.1039/b813677g

Selected in RSC Chemical Biology Research Articles Virtual Journal

[15] Autonomous DNA Computing Machine based on Photochemical Gate Transition
Shinzi Ogasawara; Takehiro Ami; Kenzo Fujimoto
J. Am. Chem. Soc., 2008, 130(31), 10050,
DOI: 10.1021/ja802583z

Research Highlight paper from Nature Asia Materials

[14] Ultrafast Reversible Photocrosslinking Reaction: Toward in Situ DNA Manipulation
Yoshinaga Yoshimura; Kenzo Fujimoto
Org. Lett., 2008, 10(15), 3227,
DOI: 10.1021/ol801112j

[13] Click Chemistry as an Efficient Method of Preparing a Sensitive DNA Probe for Photochemical Ligation
Takehiro Ami ; Kenzo Fujimoto
ChemBioChem, 2008, 9(13), 2071,
DOI: 10.1002/cbic.200800316

[12] A Light-Controlled Reversible DNA Photoligation via Carbazole Tethered 5-Carboxyvinyluracil
Kenzo Fujimoto; Hideaki Yoshino; Takehiro Ami; Yoshinaga Yoshimura; Isao Saito
Org. Lett., 2008, 10(3), 397,
DOI: 10.1021/ol7026784

[11] Cy3-3-Acylcholine: a Fluorescent Analogue of Acetylcholine for Single Molecule Detection
Kenzo Fujimoto; Yoshinaga Yoshimura; Makoto Ihara; Kazuhiko Matsuda; Takaaki Aoki; Toru Ide
Bioorg.Med.Chem.Lett, 2008, 18, 1106,
DOI: 10.1016/j.bmcl.2007.12.002

[10] DNA Photoligation in Two-color Detection of DNA Point Mutation
Takehiro Ami; Genki Ozaki; Yoshinaga Yoshimura; Kenzo Fujimoto
Chem. Lett., 2008, 37(2), 134,
DOI: 10.1246/cl.2008.134

[9] Photochemical Site-specific Mutation of 5-Methylcytosine to Thymine
Takashi Matsumura; Masayuki Ogino; Kango Nagayoshi; Kenzo Fujimoto
Chem. Lett., 2008, 37(1), 94,
DOI: 10.1246/cl.2008.94

[8] C8-alkynyl- and alkylamino substituted 2-deoxyguanosines: a universal linker for nucleic acids modification
Yoshio Saito; Katsuhiko Matsumoto; Subhendu Sekhar Bag; Shinji Ogasawara; Kenzo Fujimoto; Kazuo Hanawa; Isao Saito
Tetrahedron, 2008, 64(16), 3578,
DOI: 10.1016/j.tet.2008.01.091

[7] Photosensitized Cleavage of the Thymine Dimer in DNA via Carbazole Nucleoside
Yoshinaga Yoshimura; Yuta Taya; Hiroshi Matsumura; Kenzo Fujimoto
Journal of Photopolymer Sciecne and Technology, 2008, 21(4), 525,
DOI: 10.2494/photopolymer.21.525

[6] Sensitive DNA probe for photochemical ligation prepared in click chemistry
Takehiro Ami; Hiroshi Matsumura; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2008, 52, 247,
DOI: 10.1093/nass/nrn125

[5] Synthesis of a Photoresponsive α-Dideoxyuridine Triphosphate Derivative
Yukari Nitta; Masayuki Ogino; Yoshinaga Yoshimura; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2008, 52, 293,
DOI: 10.1093/nass/nrn148

[4] Development of template-directed reversible photocrosslinking reaction
Yoshinaga Yoshimura; Genki Ozaki; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2008, 52, 423,
DOI: 10.1093/nass/nrn215

[3] Effective Synthesis of Photosensitive Oligodeoxynucleotide
Masayuki Ogino; Yuuta Taya; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2008, 52, 395,
DOI: 10.1093/nass/nrn201

[2] 秒単位で光操作できる光応答性核酸
藤本健造
ケミカルエンジニヤリング, 2008, 53(11),

[1] 酵素を使わずに光で遺伝子を操るー人工塩基と光反応を用いた新機能の発現に期待ー
藤本健造
化学と生物（日本農芸化学会）, 2008, 46(3), 160,

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2007

[13] A Highly Efficient Method of Constructing a Single-Stranded Comb-like Oligonucleotide via Reversible Photocrosslinking
Shinzi Ogasawara; Yoshinaga Yohshimura; Masayuki Hayashi; Isao Saito; Kenzo Fujimoto
BCSJ, 2007, 11(80), 2124,
DOI: 10.1246/bcsj.80.2124

Selected as BCSJ award article from Chemical Society of Japan
Selected as Front Cover

[12] Sequence Specific Interstrand Photocrosslinking for Effective SNP Typing
Takehiro Ami; Katsuya Ito; Yoshinaga Yoshimura; Kenzo Fujimoto
Organic & Biomolecular Chemistry, 2007, 5, 2583,
DOI: 10.1039/B708264A

Highlighted Paper in the magazine Chemical Technology edited by Royal Society of Chemistry
Selected in RSC Chemical Biology Research Articles Virtual Journal
Front Cover as Org. Biomol. Chem., 2007, 5, 2509

[11] Reversible Photopadlocking on Double-Stranded DNA
Kenzo Fujimoto; Shigeo Matsuda; Yoshinaga Yoshimura; Takehiro Ami ; Isao Saito
Chemical Communications, 2007, 28, 2698,
DOI: 10.1039/B707524C

Top Ten most accessed articles from Chemical Biology Research Articles in July 2007
Highlighted Paper in the magazine Chemical Biology edited by Royal Society of Chemistry
Selected in RSC Chemical Biology Research Articles Virtual Journal

[10] Heat-resistant DNA Tile Arrays Constructed by Template-directed Photoligation through 5-Carboxyvinyl-2
Miho Tagawa; Koh-ichiroh Shohda; Kenzo Fujimoto; Tadashi Sugawara; Akira Suyama
Nucleic Acids Research, 2007, 35(21), e140,
DOI: 10.1093/nar/gkm872

[9] Non-enzymatic Parallel DNA Logic Circuits
Shinzi Ogasawara; Yoshiaki Kyoi; Kenzo Fujimoto
ChemBioChem, 2007, 8(13), 1520,
DOI: 10.1002/cbic.200700319

毎日新聞、北國新聞に関連記事

[8] Replication of cyclobutane pyrimidine dimer analogue by Ex Taq DNA polymerase
Masayuki Ogino; Daisuke Okamura; Kenzo Fujimoto
Science Technology of Advanced Materials, 2007, 8, 318,
DOI: 10.1016/j.stam.2007.01.004

[7] Highly sequence specific RNA terminal labeling by DNA photoligation
Yoshinaga Yoshimura; Yuuki Noguchi; Kenzo Fujimoto
Organic & Biomolecular Chemistry, 2007, 5, 139,
DOI: 10.1039/B615715G

Inside front cover
Promotional Paper in chemical biology supplement by Editor

[6] Parallel Processable Light-driven DNA Logic Gate
Shinzi Ogasawara; Takehiro Ami; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2007, 51, 235,
DOI: 10.1093/nass/nrm118

[5] Effective Two-color SNP Typing Based on Photoligation
Takehiro Ami; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2007, 51, 231,
DOI: 10.1093/nass/nrm116

[4] Photochemical Synthesis of R-shaped DNA via 5-Cyanovinyldeoxyuridine
Masayuki Ogino; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2007, 51, 325,
DOI: 10.1093/nass/nrm163

[3] Photochemical Transition of 5-methylcytosine to Thymine by DNA Photoligation
Takashi Matsumura; Yoshinaga Yoshimura; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2007, 51, 233,
DOI: 10.1093/nass/nrm117

[2] 光応答性人工核酸を用いた遺伝子操作および遺伝子解析
藤本健造
有機合成化学協会誌総合論文, 2007, 65(7), 709,

[1] 光による遺伝子操作法の開発
藤本健造
化学フロンティア「ゲノム化学」化学同人出版, 2007, 17,

↑ページトップへ

2006

[15] Photochemical Synthesis of R-Shaped DNA toward in vitro DNA Recombination and Processing
Masayuki Ogino; Kenzo Fujimoto
Angewandte Chemie Int. Ed., 2006, 45, 7233,

[14] Highly selective and sensitive template-directed photoligation of DNA via 5-carbamoylvinyl-2-deoxyuridine
Yoshinaga Yoshimura; Daisuke Okamura; Masayuki Ogino; Kenzo Fujimoto
Org. Lett., 2006, 8(22), 5049,

[13] SNP Genotyping using Photochemical Ligation
Shinzi Ogasawara; Kenzo Fujimoto
Angewandte Chemie Int. Ed., 2006, 45, 4512,

Hot Paper chosen by Editor Press Release from Editorial Office

[12] Site-specific Transition of Cytosine to Uracil via Reversible DNA Photoligation
Kenzo Fujimoto; Shigeo Matsuda; Yoshinaga Yoshimura; Takashi Matsumura; Masayuki Hayashi; Isao Saito
Chemical Communications, 2006, 30, 3223,

Promotional Paper in chemical biology supplement by Editor Hot off the Press from Editorial Office referred in Mol. BioSyst., 2006, 2, 457-461

[11] Template-directed DNA photoligation in rapid and selective detection of RNA point mutations
Yoshinaga Yoshimura; Yuuki Noguchi; Kenzo Fujimoto
ChemBioChem, 2006, 7(4), 598,

Hot Topics in RNA study chosen by Wiley InterScience Journal

[10] Catalytic Repair of a Thymine Dimer in DNA via Carbazole Nucleoside
Yoshinaga Yoshimura; Kenzo Fujimoto
Chem. Lett., 2006, 35(4), 386,

[9] Fluorescence labeling of DNA based on photochemical ligation
Takehiro Ami; Kenzo Fujimoto
Science Technology of Advanced Materials, 2006, 7, 249,

[8] A Quick Fix for Damaged Genes
Kenzo Fujimoto; Shigeo Matsuda; Yoshinaga Yoshimura; Takashi Matsumura; Masayuki Hayashi; Isao Saito
Chemical Biology, 2006, 1, 9.33,

[7] Heat-resistant DNA arrays constructed by self-assembly
Miho Tagawa; Koh-ichiroh Shohda; Kenzo Fujimoto; Akira Suyama
Proc. of NanoBio-Tokyo, 2006, 383-384,

[6] Nucleotide insertion opposite a cyclobutane pyrimidine dimer analogue caused from photoligation by a replicative DNA polymerase
Masayuki Ogino; Daisuke Okamura; Yoshinaga Yoshimura; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2006, 50, 125,

[5] Photoinduced repair of a thymine dimer in DNA via carbazole nucleoside
Yoshinaga Yoshimura; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2006, 50, 151,

[4] High selectivity detection of point mutation by DNA photochemical cross-linking
Shinzi Ogasawara; Kenzo Fujimoto
Nucleic Acids Symp. Series, 2006, 50, 173,

[3] 光応答性核酸を用いた遺伝子操作法の開発
藤本健造
生物物理（生物物理学会）総説, 2006, 46(3), １50,

[2] 酵素を使わずに光を用いる遺伝子操作
藤本健造
実用産業情報, 2006, 39, 17,

[1] 酵素を用いない光を使ったDNAハンドリング
藤本健造; 吉村嘉永
OHM社、「HEADLINE REVIEW 2006 先端科学技術要覧」, 2006, 6(8), 402,

↑ページトップへ

2005

[11] A Novel Method to Synthesize Versatile Multiple-Branched DNA (MB-DNA) by Reversible Photochemical Ligation
Shinzi Ogasawara; Kenzo Fujimoto
ChemBioChem, 2005, 10(6), 1756,

[10] Template-directed DNA photoligation via a -5-cyanovinyldeoxyuridine
Masayuki Ogino; Yoshinaga Yoshimura; Akio Nakazawa; Isao Saito; Kenzo Fujimoto
Org. Lett., 2005, 14, 2853,

[9] Photoinduced DNA end capping via N3-methyl-5-cyanovinyl-2-deoxyuridine
Kenzo Fujimoto; Yoshinaga Yoshimura; Tadayoshi Ikemoto; Akio Nakazawa; Masayuki Hayashi; Isao Saito
Chemical Communications, 2005, 25, 3177,

[8] Interstrand Photocrosslinking of DNA via p-Carbamoylvinyl Phenol Nucleoside
Yoshinaga Yoshimura; Yoshiaki Ito; Kenzo Fujimoto
Bioorg.Med.Chem.Lett , 2005, 15(5), 1299,

[7] Solution of a SAT Problem on a Photochemical DNA Computer
Shinzi Ogasawara; Kenzo Fujimoto
Chem. Lett., 2005, 34(3), 378,

[6] Template Directed Photoreversible ligation of DNA via carboxyvinyl-deazaadenosine
Isao Saito; Yohei Miyauchi; Yoshio Saito; Kenzo Fujimoto
Tetrahedron Lett., 2005, 46, 97,

[5] Photochemical ODN Manipulation Based on Reversible DNA Photoligation Mediated by Modified Photoresponsive Base
Masayuki Ogino; Shinzi Ogasawara; Takehiro Ami; Kenzo Fujimoto
Journal of Photopolymer Sciecne and Technology, 2005, 15(5), 1299,

[4] Photo-triggered ODN manipulation on DNA chip
Shinzi Ogasawara; Kenzo Fujimoto
Nucleic Acid Res. Suppl., 2005, 49, 141,

[3] RNA template-directed photoligation via 5-carboxyvinyl-2
Yoshinaga Yoshimura; Yuuki Noguchi; Hideaki Sato; Kenzo Fujimoto
Nucleic Acid Res. Suppl., 2005, 49, 143,

[2] 光DNAコンピューティング
藤本健造
光化学, 2005, 36(1), 63,

[1] 酵素を用いない光を使ったDNAハンドリング
藤本健造; 吉村嘉永
OHM社、月刊「OHM」, 2005,

↑ページトップへ

2004

[5] Reversible DNA Photoligation via a-5-Cyanovinyldeoxyuridine
Masayuki Ogino; Yoshinaga Yoshimura; Akio Nakazawa; Isao Saito; Kenzo Fujimoto
Nucleic Acid Res. Suppl., 2004, 4, 77,

[4] DNA Computing based on Photochemical Ligation of DNA
Shinzi Ogasawara; Naoto Kishi; Kenzo Fujimoto
Adv. Mat. Sci. Tech, 2004, 5, 91,

[3] Interstrand DNA Photocrosslinking by Photoresponsive Artificial Nucleic Acid
Yoshinaga Yoshimura; Yoshiaki Ito; Kenzo Fujimoto
Nucleic Acid Res. Suppl , 2004, 4, 81,

[2] Phototriggered Reactions of DNA and Their Applications” in“Hyper Structures Molecules III” H. Sasabe, Eds., Chapter 12, 190-195
Isao Ｓaito; Kiyohiko Kawai; Takashi Nakamura; Shigeo Matsuda; Kenzo Fujimoto
Taylor & Francis, London & NY, 2004,

[1] 光で連結・開裂できる人工DNA
藤本健造
日経先端技術, 2004, 64,

↑ページトップへ

2003

[2] Photochemical DNA computing via 5-Carboxy-vinyluracil
Naoto Kishi; Masayuki Ogino; Yoshinaga Yoshimura; Isao Saito; Kenzo Fujimoto
Nucleic Acid Res. Suppl, 2003, 2, 185-186,

[1] Genetic, enzymatic, and structural analyses of phenylalanyl-tRNA synthetase from thermococcus kodakaraensis KOD1
Kentaro Shiraki; Masao Tsuji; Yoshiteru Hashimoto; Kenzo Fujimoto; Shinsuke Fujiwara; Masahiro Takagi; Tadayuki Imanaka
J. Biochem, 2003, 134, 567,

↑ページトップへ

2002

[3] Conformation Dependent DNA Photoligation via Sensitizer Tethered 5-Carboxy-vinyluracil
Kenzo Fujimoto; Naoki Ogawa; Shigeo Matsuda; Isao Saito
Nucleic Acid Res. Suppl, 2002, 2, 185-186,

[2] Deoxyribonolactone Formation in Photoirradiation of 5-Bromouracil-containing oligonucleotides by direct C1 Hydrogen Abstraction
Kenzo Fujimoto; Yutaka Ikeda; Shigenori Ishihara; Isao Saito
Tetrahedron Lett, 2002, 43, 2243-2245,

[1] 次世代遺伝子工学としての遺伝子光学--ポストゲノム時代において
藤本健造
物性研究, 2002, 79(3), 395-399,

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